12/11/2023 0 Comments Cashew plant maranon![]() ![]() The nut of the cashew fruit is well-known, owing to its aroma and flavor, and is thus commonly consumed in roasted form, as well as used in juice and alcohol production. These are important wellsprings of improvements for people who have been treated or prevented by outdated innovations ( Salas-Salvado et al., 2011). One of the food groups that is promising as a dietary intervention for brain damage is the cashew ( Anacardium occidentale L.), a type of tree nut. Thus, roasted cashew nuts could be used as a nutraceutical or functional food to treat cisplatin-induced neurotoxicity. Roasted cashew nut enhanced diet additionally forestalled neuronal degeneration in rat brain. The roasted cashew nut supplemented diet also boosted redox equilibrium and displayed protection against cispaltin-induced oxidative damage to rats' brains by an increase in SOD, CAT, GST and GPx activities, TAC, T-SH, NPSH and NO levels as well as a considerable drop in ROS and RBARS levels. Our outcomes demonstrated that roasted cashew nut enhanced diet showed inhibitory impact on activities of AChE, BChE, ADA, MAO and arginase in cisplatin-induced rats. The following oxidative stress indicators were also measured in the rat brain: glutathione-S-transferase (GST), glutathione peroxidase (GPx), total antioxidant capacity (TAC), total thiol (T-SH), non-protein thiol (NPSH), thiobarbituric acid reactive substances (TBARS), reactive oxygen species (ROS), nitric oxide (NO), superoxide dismutase (SOD). Key enzymes associated with brain function, including cholinesterases (AChE and BChE), monoaminergic enzyme (MAO), arginase, and adenosine deaminase (ADA), were investigated after the treatment. Rats were separated in to six groups: Control, CIS (cisplatin ), CIS +10% CN (cisplatin plus 10% roasted cashew nut), CIS +20% CN (cisplatin plus 20% roasted cashew nut), 10% CN (10% roasted cashew nut) and 20% CN (20% roasted cashew nut) for 28 days. This examination tried to explore the neuroprotective impact of roasted cashew nut-enhanced diet against brain deficits related with treatment with cisplatin. The incessant dose constraining symptom of the chemotherapeutic agent, cisplatin is neurotoxicity. ![]()
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